Biologia computacional, modelação de fenómenos biológicos, como a retinopatia diabética e o desenvolvimento de tumores.

Research Highlights

Observation of a new particle in the search for the Standard Model Higgs boson with the ATLAS detector at the LHC
ATLAS Collaboration, J. Carvalho
Physics Letters B 716, 1-29 (2012)
The ATLAS Experiment at the CERN Large Hadron Collider
ATLAS Collaboration, J. Carvalho
Journal of Instrumentation 3 (2008)
Tests of CPT symmetry and quantum mechanics with experimental data from CPLEAR
CPLEAR Collaboration, J. Carvalho
Physics Letters B 364, 239-245 (1995)
Limits for the central production of Theta(+) and Xi(--) pentaquarks in 920-GeV pA collisions
ATLAS Collaboration, J. Carvalho
Physical Review Letters 93, 212003 (2004)
Probing anomalous Wtb couplings in top pair decays
J. A. Aguilar-Saavedra, J. Carvalho, N. Castro, A. Onofre, F. Veloso
European Physical Journal C 50, 519-533 (2007)

Publications [LaTeX]

Papers

International Journals

1 - E-cadherin variants associated with oral facial clefts trigger aberrant cell motility in a REG1A-dependent manner
J. Pereira, S. Melo, R.M. Ferreira, P. Carneiro, V.T. Yang, A.F. Maia, J. Carvalho, C. Figueiredo, J.C. Machado, E. Morais-de-Sá, R. Seruca, J. Figueiredo
Cell Commun. Signal. 22 (1), 152 (2024)

2 - A mathematical model of fibrinogen-mediated erythrocyte-erythrocyte adhesion
CS Lopes, J Curty, FA Carvalho, A Hernandez-Machado, K Kinoshita, NC Santos, RDM Travasso
Commun. Biol. 6(1), 192 (2023)

3 - The ECM and tissue architecture are major determinants of early invasion mediated by E-cadherin dysfunction
S Melo, P Guerrero, MM Soares, JR Bordin, F Carneiro, P Carneiro, MB Dias, J Carvalho, J Figueiredo, R Seruca, RDM Travasso
Commun. Biol. 6 (1), 1132 (2023)

4 - A computational model of organism development and carcinogenesis resulting from cells bioelectric properties and communication
Carvalho, J
Sci. Rep. 12(1) (2022)

5 - A multiscale cell-based model of tumor growth for chemotherapy assessment and tumor-targeted therapy through a 3D computational approach
SJ Nivlouei, M Soltani, E Shirani, MR Salimpour, R Travasso, J Carvalho
Cell Prolif. 55(3), e13187 (2022)

6 - A bioelectric model of carcinogenesis, including propagation of cell membrane depolarization and reversal therapies
Carvalho, J
Sci Rep 11, 13607 (2021)

7 - Tumor cell invasiveness in the initial stages of bladder cancer development - A computational study
J. Carvalho, V. Lopes, R. Travasso
Int J Numer Method Biomed Eng. 37(1), e3417 (2021)

8 - A three dimensional computer model of urothelium and bladder cancer initiation, progress and collective invasion
J. Carvalho, V. Lopes, R. Travasso
Inform. Med. Unlocked 26, 100750 (2021)

9 - Cell Reversal From a Differentiated to a Stem-Like State at Cancer Initiation
Carvalho, J
Front. Oncol. 10, 541 (2020)

10 - Tumor cell invasiveness in the initial stages of bladder cancer development - A computational study
J Carvalho, V Lopes, R Travasso
Int J Numer Method Biomed Eng, e3417 (2020)

11 - Cofilin-1 Is a Mechanosensitive Regulator of Transcription
C Domingues, AM Geraldo, SI Anjo, A Matos, C Almeida, I Caramelo, JA Lopes-da-Silva, A Paiva, J Carvalho, RP das Neves, B Manadas, M Graos
Front. Cell Dev. Biol. 8, 678 (2020)

12 - Soft culture substrates favor stem-like cellular phenotype and facilitate reprogramming of human mesenchymal stem/stromal cells (hMSCs) through mechanotransduction
H Gerardo, A Lima, J Carvalho, JRD Ramos, S Couceiro, RDM Travasso, RP das Neves, M Graos
Sci. Rep. 9, 9086 (2019)

13 - Capillary network formation from dispersed endothelial cells: Influence of cell traction, cell adhesion, and extracellular matrix rigidity
João R. D. Ramos, Rui Travasso, João Carvalho,
Phys. Rev. E 97, 012408 (2018)

14 - Angiogenic Factors produced by Hypoxic Cells are a leading driver of Anastomoses in Sprouting Angiogenesis – a computational study
Maurício Moreira-Soares, Rita Coimbra, Luís Rebelo, João Carvalho, Rui D. M. Travasso,
Scientific Reports 8, 8726 (2018)

15 - A local uPAR-plasmin-TGFβ1 positive feedback loop in a qualitative computational model of angiogenic sprouting explains the in vitro effect of fibrinogen variants
Sonja E. M. Boas, Joao Carvalho, Marloes van den Broek, Ester M. Weijers, Marie-José Goumans, Pieter Koolwijk, Roeland M. H. Merks
PLoS Comput Biol 14, e1006239 (2018)

16 - Stationarity of the inter-event power-law distributions
Yerali Gandica , João Carvalho , Fernando Sampaio dos Aidos , Renaud Lambiotte , Timoteo Carletti
PLOS One 12(3): e0174509 (2017)

17 - Wikipedia editing dynamics
Y. Gandica, J. Carvalho, F. Sampaio dos Aidos
PHYSICAL REVIEW E 91, 012824 (2015)

18 - The dynamic nature of conflict in Wikipedia
Y. Gandica, F. Sampaio dos Aidos, J. Carvalho
Eur. Phys. Lett. 108, 18003 (2014)

19 - Observation of a new particle in the search for the Standard Model Higgs boson with the ATLAS detector at the LHC
ATLAS Collaboration, J. Carvalho
Physics Letters B 716, 1-29 (2012)

20 - The ATLAS Experiment at the CERN Large Hadron Collider
ATLAS Collaboration, J. Carvalho
Journal of Instrumentation 3 (2008)

21 - Probing anomalous Wtb couplings in top pair decays
J. A. Aguilar-Saavedra, J. Carvalho, N. Castro, A. Onofre, F. Veloso
European Physical Journal C 50, 519-533 (2007)

22 - Limits for the central production of Theta(+) and Xi(--) pentaquarks in 920-GeV pA collisions
ATLAS Collaboration, J. Carvalho
Physical Review Letters 93, 212003 (2004)

23 - Tests of CPT symmetry and quantum mechanics with experimental data from CPLEAR
CPLEAR Collaboration, J. Carvalho
Physics Letters B 364, 239-245 (1995)

Proceedings

International Conferences

24 - A cellular Potts model describing wound healing assays in diverse cell motility and cell adhesion conditions
J Carvalho, S Jafari, G Martins
Eur. J. Clin. Invest. 52(1) (2022)

25 - Three dimensional computer model of urothelium, bladder cancer development and collective tumor invasion
J Carvalho, V Lopes, R Travasso
Eur. J. Clin. Investig. 51, 104-104 (2021)

26 - Circadian Patterns on Wikipedia Edits
Y. Gandica, R. Lambiotte, T. Carletti, F. Sampaio dos Aidos, J. Carvalho
Complex Networks VII 644, 293-300 (2016)

Communications

Invited

27 - Angiogenic Factors Produced by Hypoxic Cells drive Anastomoses in Sprouting Angiogenesis
Rui DM Travasso, Mauricio Soares, Rita Coimbra Luís Rebelo , João Carvalho
University of Castilla la Mancha, Ciudad Real, Spain, 29th Jun (2017)

28 - Mechanically-driven pattern formation in cell cultures
João R. D. Ramos, Rui Travasso, João Carvalho
mini-symposium Angiogenesis and cell motility, in Mathematics of Complex Systems: from precision medicine to smart cities, Coimbra, Portugal, 5th-6th Dec (2016)

29 - Angiogenic factors produced by hypoxic cells drive anastomosis in sprouting angiogenesis
M. M. Soares, L. Rebelo, R. Coimbra, J. Carvalho, R. D. M. Travasso,
mini-symposium Angiogenesis and cell motility, in Mathematics of Complex Systems: from precision medicine to smart cities, Coimbra, Portugal, 5th-6th Dec (2016)

Oral

30 - Influence of the Underlining Duct Structure in Prostate Adenocarcinoma Progression
F. Paiva, J. Carvalho, G. Lorenzo, R. Travasso
Encontro Novos Talentos em Física, Coimbra, Portugal, 23rd–24th Jul (2022)

31 - Influence of the Underlining Duct Structure in Prostate Adenocarcinoma Progression
F. Paiva, J. Carvalho, G. Lorenzo, R. Travasso
Research School and Workshop on Mathematical Modeling of Self Organization in Medicine, Biology and Ecology, Palermo, Italy, 30th May – 3rd Jun (2022)

32 - Role of prostate gland network structure in early stage prostate cancer growth
António Sérgio Morais, Guillermo Lorenzo, Rui DM Travasso, João Carvalho
55th Annual Scientific Meeting of ESCI, 9th - 11th Jun (2021)

33 - Role of prostate gland network structure in early stage prostate cancer growth
António Sérgio Morais, Guillermo Lorenzo, Rui DM Travasso, João Carvalho
Virtual SMB 2021 Annual Meeting, 13th - 17th June (2021)

34 - Three dimensional computer model of urothelium, bladder cancer development and collective tumor invasion
João Carvalho, Valéria Lopes, Rui Travasso
55th Annual Scientific Meeting of ESCI, 9th - 11th Jun (2021)

35 - 3D Multiscale Modeling of Chemotherapeutic Drug Delivery to Malignant Tumors
Sahar Jafari Nivlouei, M Soltani, João Carvalho, Rui DM Travasso, Mohammad Reza Salimpour, Ebrahim Shirani
55th Annual Scientific Meeting of ESCI, 9th - 11th Jun (2021)

36 - 3D Multiscale Modeling of Chemotherapeutic Drug Delivery to Malignant Tumors
Sahar Jafari Nivlouei, M Soltani, João Carvalho, Rui DM Travasso, Mohammad Reza Salimpour, Ebrahim Shirani
Virtual SMB 2021 Annual Meeting, 13th - 17th June (2021)

37 - Tumor angiogenesis: a mathematical model in three dimensions
M. M. Soares, L. Rebelo, R. A. Coimbra, J. Carvalho, R. D. M. Travasso,
Physical Biology of Tissue Morphogenesis - Mechanics, Metabolism and Signaling, Dresden, Germany, 17th-21st Oct (2016)

38 - Vascular Growth in Tumor Angiogenesis: a Mathematical Model in Three Dimensions
Rita Coimbra, Maurício Moreira-Soares , João Carvalho, Rui DM Travasso
Física 2016, Braga, Portugal, 8th-10th Sep (2016)

39 - Reconstrução Automática da Rede Capilar da Retina de um Paciente
Rute Marto, Luís Cruz, Rui DM Travasso, João Carvalho
Presentation of Projects in Biomedical Engineering, Coimbra, Portugal, 30th May (2016)

40 - Regulation of Blood Vessel Growth
Patrícia Oliveira, Rui DM Travasso, João Carvalho, Orlando Oliveira
Presentation of Projects in Biomedical Engineering, Coimbra, Portugal, 30th May (2014)

Poster

41 - Modelling the growth of glioblastomas
Marina Oliveira, João Carvalho, Rui DM Travasso
Presentation of Projects in Biomedical Engineering, Coimbra, Portugal, 9th Feb (2018)

42 - Modelling the growth of glioblastomas
Marina Oliveira, João Carvalho, Rui DM Travasso
Presentation of Projects in Biomedical Engineering, Coimbra, Portugal, 1st Jun (2018)

43 - Tumor Angiogenesis: a Mathematical Model in Three Dimensions
Maurício Moreira-Soares , Rita Coimbra, João Carvalho, Rui DM Travasso
Ciência 2016, Lisbon, Portugal, 4th-6th Jul (2016)

44 - Vascular Growth in Tumor Angiogenesis: a Mathematical Model in Three Dimensions
Rita Coimbra, Maurício Moreira-Soares, João Carvalho, Rui DM Travasso
Porto Meetings in Mathematics and Biology, Porto, Portugal, 15th-17th Jun (2016)

45 - Reconstrução Automática da Rede Capilar da Retina de um Paciente
Rute Marto, Luís Cruz, Rui DM Travasso, João Carvalho
Presentation of Projects in Biomedical Engineering, Coimbra, Portugal, 10th Feb (2016)

46 - Regulation of Blood Vessel Growth
Patrícia Oliveira, Rui DM Travasso, João Carvalho, Orlando Oliveira
Presentation of Projects in Biomedical Engineering, Coimbra, Portugal, 12th-14th Feb (2014)