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Co0.85Bi0.15Fe1.9X0.1O4 (X = Ce4+, Sm3+, Ho3+, and Er3+) Nanoparticles with Selective Anticancer Activity: A Structural and Morphological Approach
Authors: Saher, L.; Benali, A.; Haddad, S.; Dhahri, E.; Graca, M.P.F.; Costa, B.F.O.; Helguero, L.A.; Silva, A.M.S.
Ref.: Crystals 15(5), 482 (2025)
Abstract: In this work, we synthesized the Co0.85Bi0.15Fe1.9X0.1O4 (X = Ce3+, Sm3+, Ho3+, and Er3+) nanoparticles via the auto-combustion method. The cell viability against two breast cancer cells (MDA-MB-231 and T-47D cells) and the PC3 prostate cancer cells were carefully analyzed and correlated with the structural parameters and particle size values as well as the chemical composition. The produced compounds´ morphological and structural characteristics were performed using scanning transmission microscopy (TEM) and X-ray Diffraction (XRD). For all compounds, the analyses of the XRD experimental data revealed a structurally reversed cubic spinel with space group Fd-3m. All of the compounds had crystallites smaller than 45 nm which concorded well with the particle size values deduced from TEM images. Co0.85Bi0.15Fe1.9Ho0.1O4 nanoparticles induced a high mortality of breast and prostate cancer cells (MDA-MB-231, T-47D, and PC3) while the Co0.85Bi0.15Fe1.9Sm0.1O4 compound (higher particle size) reduced almost 35% of MDA-MB-231 cancer cells. With very low cytotoxicity against normal human cells, the Co0.85Bi0.15Fe1.9Ho0.1O4 nanoparticles play a significant role in the elimination of cancer cells.
