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Understanding the Dynamics of Tumor Angiogenesis: A Systems Biology Approach

Authors: MM Quinas-Guerra, TM Ribeiro-Rodrigues, JC Rodríguez-Manzaneque, RDM Travasso

Ref.: Systems Biology in Cancer Research and Drug Discovery, Ed. A Azmi, Springer Netherlands, 197-227 (2012)

Abstract: The process of sprouting angiogenesis is extremely complex involving hundreds of proteins that regulate transcription and participate in signaling pathways controlling cellular movement, proliferation and phenotype alteration. Modeling has been attempted to understand all these mechanisms, and hence, in this chapter, we will focus on models that deal individually with each one of these mechanisms relevant to angiogenesis, as well as with platforms that integrate various models into multiscale models of the whole process.

DOI: 10.1007/978-94-007-4819-4_8

URL: link.springer.com